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Sr. Scientist/Principal Scientist, Immunology  

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.

There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

Astellas is announcing a Sr. Scientist, Immunology opportunity at their new affiliate Xyphos in South San Francisco, CA.



The primary purpose of the Immunology Senior Scientist is to lead platform innovation efforts and engage with cross-functional teams to identify ways in which the convertibleCARTM and BiKE platforms can be best leveraged to promote function in diverse tumor environments.


Essential Job Responsibilities:

  • Leads efforts to identify and implement, in a focused manner, additional modalities that will complement and enhance convertibleCARTM functions
  • Develops and executes on cell-based functional assays to generate data supporting the selection of a tumor target
  • Designs and develops analytical assays to characterize immune cell function
  • Processes and condenses data for efficient, organized, and thoughtful presentation during internal meetings
  • Provide scientific expertise, including maintaining familiarity with relevant scientific literature, and mentor others in relevant research
  • Performs other duties as assigned or special projects as needed



  • A PhD in immunology or a related discipline with 5+ years of relevant post-graduate experience
  • Extensive hands-on experience with all immunology-related analytical tools -- multi-parametric flow cytometry and state-of-the art cytokine profiling and quantifying
  • Experience in the engineering of immune cells -- lentiviral transduction or other forms of gene delivery, e.g. CRISPR, transposon, nanoparticle, and RNP-mediated deliveries
  • Experience working with adoptive cell therapies and antibody based therapies and a good breadth of understanding of the current immuno-oncology space
  • Solid understanding of the tumor micro-environment and its impact on the effectiveness of adoptive cell therapies
  • Demonstrated excellence in critical thinking and problem solving skills
  • Excellent communication and interpersonal skills
  • Ability to work independently, to mentor, and to effectively collaborate with other teams
  • Excellent work planning, organization, record keeping and attention to detail
  • Strong work ethic with a passion for working in a fast-paced, dynamic and diverse work environment



  • Strong immunology background with understanding of T-cell and NK cell biology, cytokine function, and overall aspects of how adaptive and innate immune cells interface with other parts of the immune system
  • Experience managing projects and teams highly preferred


Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
Type Full-time
Location CA, South San Francisco
Category Research and Development

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