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Senior Research Associate  

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.

There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

Astellas is announcing a Senior Research Associate Exploratory Biology opportunity at their new affiliate Mitobridge in Cambridge, MA.



Mitobridge is seeking a highly motivated, Research Associate to join our Exploratory Biology group and participate in drug discovery programs that lead to the identification of new targets. The primary focus of this position is to conduct high quality bench research and to develop biochemical and cellular assays that will contribute to our drug discovery efforts.


Essential Job Responsibilities:

  • Design and perform biochemical and cellular assays under the direction of the leading scientist to identify and validate new targets.
  • Generate new cell lines and disease models using genetic manipulation techniques such as CRISPR, shRNA, RNAi, lentiviral/retroviral transduction.
  • Evaluate new targets by using western blotting, immunoprecipitation, ELISA assays.
  • Develop phenotypic assays using microscopy, immunocytochemistry, low throughput as well as high throughput high content imaging to enable small molecule discovery.
  • Assist the exploratory biology group with the development of cell-based assays including flow cytometry, live cell imaging, and FRET.
  • Use molecular biology tools such as cloning, RNA/DNA analysis, qPCR and Nanostring to support advancement of our early stage programs.
  • Collaborate with other members of the group and present their work at regular department meetings.


Quantitative Dimensions:

This position directly impacts our ability to prosecute our company goals of maintaining an early stage pipeline of potential drug candidates. The measures of success are the advancement of new targets through the successive stages of the drug discovery pipeline.

 Their components are:

  • Efficient and technically competent execution of lab work designed to advance early stage projects.
  • Accurately interpret experimental data, perform statistical analysis, formulate conclusions and communicate data with colleagues.
  • Maintenance of accurate and up to date records of experimental data.
  • Presentation of data at regular internal meetings.



  • Bachelor's degree with 5+ years of drug discovery experience or Master's Degree with 2+ years experience.
  • Prior experience conducting high quality science in an industry setting.
  • Demonstrated ability to think logically and critically with excellent organizational skills and attention to detail.
  • Team player with strong written and oral communication skills.
  • Able to work productively and to participate in a highly creative and fast-paced environment.



  • Experience in drug discovery setting


Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
Type Full-time
Location MA, Cambridge
Category Research and Development

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