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Title
Research Scientist, Mitochondrial Biology  
Description

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.

 There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

 Astellas is announcing a Research Scientist, Mitochondrial Biology opportunity at their Mitobridge facility in Cambridge, MA.

 

Purpose:

Mitobridge is seeking a highly-proficient scientist in the study of mitochondrial biology to support research focused on mitochondrial bioenergetics. Provides intellectual and technical support for new target and drug discovery programs, and peer leadership to the biology team. Primary emphasis on developing and utilizing in vitro techniques for measuring mitochondrial bioenergetics in a variety of cell types, model key aspects of disease-related cell biology and evaluate the impact of novel small molecule approaches on those phenotypes. The successful candidate will report to the director of pharmacology, who manages the mitochondrial energetics and metabolism drug development portfolio.

 

Essential Job Responsibilities:

  • Investigate relevance of mitochondrial bioenergetics in cellular models of disease.
  • Accurately interpret experimental data, perform statistical analysis, formulate conclusions and communicate data with colleagues and externally.
  • Lead research projects and programs through cross collaboration of internal and external teams
  • Maintains scientific awareness and expertise through literature and attendance at relevant conferences
  • Drive publication efforts.
  • Investigate program-relevant pathways in novel areas of mitochondrial diseases.
  • Maintain interactions with outside leaders in disease-specific areas.
  • Work with external research organizations to supplement in-house scientific goals.
  • Support training of junior laboratory members.
  • Propose and establish disease-specific tools to enable drug-discovery efforts.
  • Contribute to the company's scientific strategy.
Requirements

Qualifications:

Required

  • PhD in Physiology/Pharmacology/Biological/Biochemical Sciences or other related discipline with postdoctoral experience for Research Scientist. PhD without postdoctoral experience may be considered for an Associate Scientist position.
  • Proven track record within the area of mitochondrial bioenergetics and NAD+ biology
  • Extensive knowledge of techniques to determine in vitro, ex vivo and in vivo mitochondrial function (for example but not limited to respiration, ATP production, and/or substrate turnover)
  • Extensive knowledge of molecular and cellular mechanisms involved in mitochondrial energetics in several tissues.
  • Demonstrated aptitude for independent research and innovative thinking.
  • Experienced trainer and supervisor of lab-based scientists.
  • Demonstrated ability to accurately interpret experimental data, formulate conclusions and communicates data externally.
  • Ability to present clear and compelling scientific arguments.

 

Preferred

  • Experience working in a Biopharmaceutical company developing drug development candidates in the preclinical space.
  • Experienced in disease-relevant assay development, screening and hit to lead activities with different modalities (small molecule, biologic and gene therapy).

 

Disclaimer

The statements above are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time.

 

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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
Type Full-time
Location MA, Cambridge
Category Research and Development


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