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Title
Marie Curie Post Doctoral Fellow - Oncology/Pharmacology  
Location UK, Cambridge
Job Description

MedImmune are a global leader in Biologics research for Therapeutic use. Oncology is a key therapeutic area for a number of our research teams and as part of the CAFFEIN European collaboration we are proud to offer a Post-Doctoral position funded by the European Commission (EC).

The CAFFEIN consortium (www.caffein.ku.dk) is an FP7 EC funded Marie Curie Initial Training Network (ITN) with the objective to train young scientists in the important role of cancer associated fibroblast (CAF) for tumour cell expansion and invasion. In a trans-European network MedImmune Cambridge and ten academic partners aim to identify functional CAF subpopulations and CAF effector mechanisms, and to develop therapeutic antibodies targeting CAFs as a novel approach in cancer therapy.

CAFFEIN consists of leading European research groups and companies with complementary knowledge in this area and a critical mass of expertise for providing an excellent training in CAF function and translational cancer research. We currently seek a post-doctoral fellow with a high motivation, high interest in cancer research and the willingness to work in a team of academic and industrial partners in different European countries.

As a Marie Curie funded post all applicants must fulfil specific criteria to be eligible for consideration (This information can be identified at the end of the advert).

Should you fulfil these criteria and possess the experience outlined below this 24 month post present a significant opportunity to develop your academic and technical skills further and gain exposure to a dynamic industrial research setting.

Role Specifics

  • Understand the role of cancer associated fibroblasts (CAF) and identify therapeutic potential of targeting these cells during cancer development and progression.
  • Develop, design and run in vitro and in vivo models.
  • Understand the crosstalk between tumour cells/Immune cells and cancer associated fibroblasts, and how this affects cancer cell survival and dissemination 
  • Isolate primary cancer associate fibroblasts from primary tumours and/or relevant pre-clinical cancer models.
  • Understand how approved therapies affects the crosstalk between tumour cells and CAFs
  • Link with the technology team to establish phenotypic selection strategy for the discovery of novel drug targets and/or prognostic and responsive biomarkers
  • Pursue one or two targets and further assess the therapeutic potential using knock in and knock out strategies
  • Communicate results, conclusions and recommendations to colleagues, line manager and multi-disciplinary teams and developing a publishing strategy
  • Acquire and maintain relevant technical and intellectual expertise in stroma biology (angiogenesis immune cells and cancer associated fibroblasts), 3D models and in vivo models.
  • Be a highly organized, self-motivated individual with a strong practical background.
  • Engage regularly with the consortium collaborators and attend consortium training, knowledge generation and dissemination.
Position Requirements

Experience and skills

  • Candidates should have tumour biology experience as well as experience running co-culture (2D and 3D) and/or in vivo tumour modelling experience.
  • Cancer associated fibroblast expertise would be advantageous. Knowledge of drug discovery process particularly in a pharmaceutical environment would also be desirable.
  • A good publication record in top-tier journals
  • Must have a range of in vitro and in vivo skills that can be applied to evaluation of therapeutic antibodies for cancer. These may include:
  1. Expertise in 2D and 3D models co-culture models
  2. In vivo tumour models (subcutaneous, orthotropic and genetically engineered mouse models)
  3. Tissue culture expertise
  4. Knowledge of Home Office Regulations for in vivo work or equivalent
  5. Endpoint analysis, e.g. FACS, IHC, ELISA
  6. Data processing, analysis and interpretation
  7. Statistical analysis
  • The team is keen to expand its expertise and would value experience in the following areas: 
  1. Microarray analysis and/or Next Generation Sequencing.
  2. Experience in complex models (in vitro and in vivo)
  3. Analysis of pharmacokinetic parameters

Education & Qualifications:

  • First degree, HND/HNC in biological sciences. 
  • PhD in biochemistry, molecular biology, cell biology, immunology, pharmacology or relevant subject with strong preclinical knowledge.
  • Home Office License (Modules 1-4) or equivalent qualification for in vivo work.

Eligibility

To be considered for the post you must fulfil the following criteria:

Academic Background: 1) At point of hire you must be in possession of a doctoral degree (PhD) independently of the time taken to acquire it and 2) have less than five years of full-time research experience (Including Phd).
e.g. If your PhD took 4 years to complete it must be less than 1 year since you completed (Graduation date).

Mobility: It's is a goal of Marie Curie to promote the mobility of Scientific Knowledge across national boundaries. Therefore candidates should NOT have resided or carried out his/her main activity (work, studies, etc.) in the UK for more than 12 months in the 3 years immediately prior to the time of recruitment. Mobility allowance will be provided to ensure you are financially compensated for your relocation.
Req ID 6834
Position Category Research
 
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